TARGIT IORT using Intrabeam 

Breast Cancer Treatment with TARGIT IORT using the Intrabeam system

 

Targeted Intraoperative Radiotherapy using Intrabeam system for Breast Cancer

TARGIT IORT uses the Intrbeam radiotherapy system and is an elegant approach of partial breast irradiation (PBI) using intraoperative radiotherapy (IORT) for breast cancer.

TARGIT, which stands for TARGeted Intraoperative radioTherapy, was coined by Professor Jayant S Vaidya to describe this technique that he invented along with Professor Michael Baum and Professor Jeffrey S Tobias in 1998

Warning:

Due to graphic surgical content this video is only available on YouTube

The TARGIT-A trial of immediate targeted intraoperative radiotherapy (TARGIT IORT) compared risk-adapted single dose IORT during lumpectomy using TARGIT technique (Intrabeam radiotherapy) vs. whole breast external beam radiotherapy

  • for patients who are 45 years or older and with breast cancer (ductal) up to 3.5cm in size

  • This trial has completed recruitment.

  • The initial results of the TARGIT-A trial were presented in ASCO 2010 and published in the Lancet in July 2010, in the Lancet in November 2013 and detailed analysis in the NIHR Library in September 2016

  • Long-term results of the TARGIT-A trial were published in the BMJ in August 2020

 

The TARGIT-B trial is investigating the superiority of a tumour bed boost with IORT using the TARGIT technique  vs. conventional external beam radiotherapy tumour bed boost. This is given in addition to whole breast radiotherapy

  • for patients who are younger than 45 years, or have a higher risk of cancer recurrence

  • and is designed to test if giving an intraoperative tumour bed boost using TARGIT is superior to the usual externally given tumour bed boost, both in addition to whole breast radiotherapy.

  • This trial started recruitment in June 2013

  • By 2020, neary 1300 patients have participated in the randomised trial from 38 centres in 15 countries

  • Please click here to read the details of this trial design

 

Both these trials are for patients who have a breast conserving surgery i.e.,  wide local excision, or lumpectomy.

 

Breast cancer patients who need a mastectomy are not currently suitable for IORT using the Intrabeam TARGIT IORT technique.

 

Recent papers about TARGIT IORT using Intrabeam.

DISCLAIMER 

References

[1]  J. Vaidya, M. Baum, J. Tobias, S. Morgan, and D. D’Souza, “The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer,” European Journal of Surgical Oncology, vol. 28, pp. 447-454, 2002. 

[2]  J. Vaidya, M. Baum, J. Tobias, D. D ‘Souza, S. Naidu, S. Morgan, M. Metexas, K. Harte, A. Sliski, and E. Thomson, “Targeted Intra-operative Radiotherapy: An Innovative Method of Treatment for Early Breast Cancer,” Annals of Oncology, vol. 12, pp. 1075-1080, 2001.