TARGIT IORT using Intrabeam
Breast Cancer Treatment with TARGIT IORT using the Intrabeam system
Targeted Intraoperative Radiotherapy using Intrabeam system for Breast Cancer
TARGIT IORT uses the Intrbeam radiotherapy system and is an elegant approach of partial breast irradiation (PBI) using intraoperative radiotherapy (IORT) for breast cancer.
TARGIT, which stands for TARGeted Intraoperative radioTherapy, was coined by Professor Jayant S Vaidya to describe this technique that he invented along with Professor Michael Baum and Professor Jeffrey S Tobias in 1998
Due to graphic surgical content this video is only available on YouTube
The TARGIT-A trial of immediate targeted intraoperative radiotherapy (TARGIT IORT) compared risk-adapted single dose IORT during lumpectomy using TARGIT technique (Intrabeam radiotherapy) vs. whole breast external beam radiotherapy
for patients who are 45 years or older and with breast cancer (ductal) up to 3.5cm in size
This trial has completed recruitment.
The initial results of the TARGIT-A trial were presented in ASCO 2010 and published in the Lancet in July 2010, in the Lancet in November 2013 and detailed analysis in the NIHR Library in September 2016
The TARGIT-B trial is investigating the superiority of a tumour bed boost with IORT using the TARGIT technique vs. conventional external beam radiotherapy tumour bed boost. This is given in addition to whole breast radiotherapy
for patients who are younger than 45 years, or have a higher risk of cancer recurrence
and is designed to test if giving an intraoperative tumour bed boost using TARGIT is superior to the usual externally given tumour bed boost, both in addition to whole breast radiotherapy.
This trial started recruitment in June 2013
By 2020, neary 1300 patients have participated in the randomised trial from 38 centres in 15 countries
Please click here to read the details of this trial design
Both these trials are for patients who have a breast conserving surgery i.e., wide local excision, or lumpectomy.
Breast cancer patients who need a mastectomy are not currently suitable for IORT using the Intrabeam TARGIT IORT technique.
Recent papers about TARGIT IORT using Intrabeam.
 J. Vaidya, M. Baum, J. Tobias, S. Morgan, and D. D’Souza, “The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer,” European Journal of Surgical Oncology, vol. 28, pp. 447-454, 2002.
 J. Vaidya, M. Baum, J. Tobias, D. D ‘Souza, S. Naidu, S. Morgan, M. Metexas, K. Harte, A. Sliski, and E. Thomson, “Targeted Intra-operative Radiotherapy: An Innovative Method of Treatment for Early Breast Cancer,” Annals of Oncology, vol. 12, pp. 1075-1080, 2001.