Publications

TARGIT literature archive (1995-2018)

Clinico-Pathological and biological rationale of partial breast irradiation (PBI) and the TARGIT-A Trial

1995    Hongkong International Cancer Congress

1996    British Journal of Cancer

1997    The Lancet

The Core trial Protocol of the Targit-A Trial

1999    The Lancet 

 

The original series of patients treated with intraoperative radiation therapy: the first full paper about Targit IORT technique

2001    Annals of Oncology

 

The surgical technique of targeted intraoperative radiotherapy  (TARGIT) for early breast cancer treatment as used in the Targit trial

 

2002    European Journal of Surgical Oncology

2002    Surgical Technique Video

2006    World Journal of Surgical Oncology (TARGIT IORT given under local anaesthetic)

 

A novel one-stop out-patient treatment for small breast cancers

2002    The Lancet

 

PhD Thesis of Jayant S Vaidya

2002    University College London PhD Thesis

 

Initial media coverage

2000    BBC Tomorrow’s World

2001     Lancet Oncology News

2002    Time Magazine

2003    Reader’s Digest

2006    Reader’s Digest

 

2003 San Antonio Breast Cancer Symposium:30-minute invited presentation about the Targit trial

2003    San Antonio Breast Cancer Symposium - first plenary on TARGIT IORT

Acute and Late Toxicity data about the Targit approach.

2004    ANZ Journal of Surgical Oncology

2005    Oncologie

2005    Tumori

2006    Int J Rad Oncol Biol Phys

2012    Breast Cancer Research and Treatment PDF

 

Reviews, Editorials, Viewpoint and Rebuttals

2004    Lancet Oncology

2004    British Journal of Radiology

2005    Seminas in Radiation Oncology

2006    Clinical Oncology 

2006    The Breast

2007    Nature Clinical Practice Oncology

2008    Annals of New York Academy of Sciences

2015    Red Journal Jun 2015 Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of  Targeted Intraoperative Radiation Therapy for Breast Cancer

 

2015    Red Journal Aug 2015- Editorial by the Chief Editor
“…..Many careers have been built around fractionated radiation therapy for breast cancer, and it comprises a substantial proportion of the practice of the average contemporary radiation oncologist. Depending on your perspective, intraoperative radiation therapy is thus either a very serious threat or a quantum leap forward.”

2017    Practical Radiation Oncology February 2017

Commentary and corrections to the 2017 ASTRO - APBI guidelines 

2018   The Lancet 6 Jan 2018 Targeted radiotherapy for breast cancer: Letter |

   Updated meta-analysis of targeted radiotherapy vs whole breast radiotherapy 

2018 BMJ Evidence Based Medicine  Commentary on IMPORT-LOW trial

2018 JAMA Oncology -TARGIT- IORT the best method of partial breast irradiation - an independent opinion

2019 Anticancer research

- TARGIT-IORT in breast cancer patients who had implant augmentation full paperSABCS poster

Meta-analyses confirming that targeted radiotherapy is effective in controlling breast cancer and reduces deaths heart attacks and other cancers

2016     Lancet April 2016

A meta-analysis of GEC-ESTRO + TARGIT-A trials show Partial Breast Irradiation (PBI) has similar breast cancer control as Whole Breast Irradiation (WBI), and fewer deaths from other causes.

2016  Red Journal 13 May 2016
Mortality reduction with Partial Breast Irradiation: A meta-analysis of randomised controlled trials

2018 The Lancet 6 Jan 2018

Updated meta-analysis of targeted radiotherapy vs whole breast radiotherapy 

Targeted radiotherapy for breast cancer: Letter

Environmental and Social impact 

2016     BMJ Open 10 May 2016
TARGIT IORT radiotherapy during lumpectomy for breast cancer could save millions of travel miles & tonnes of CO2. …plus free up thousands of hours for women with early stage breast cancer, every year. 
Video Abstract
Full paper
Press release by the BMJ

Cost-effectiveness of TARGIT 

2013     Annals of Surgical Oncology (PDF)   20:2873–2880

2016     HTA Journals  Health economics - cost effectiveness of TARGIT IORT - PDF 

2017     BMJ Open - PDF

 

Better Cosmetic outcome from TARGIT

2003    San Antonio Breast Cancer Conference 

2013     Breast Cancer Research and Treatment (PDF) 140(3):519-25.

2018     Radiation Oncology 

 

Better Quality of Life with TARGIT

2013    Radiation Oncology

2016    International Journal of Radiation Oncology Biology Physics

 

Book Chapters  

2003    Recent Advances in Surgery

2006    Accelerated Partial Breast Irradiation (1st Edition)

2009    Accelerated Partial Breast Irradiation (2nd Edition)

2016     A Short course in breast radiotherapy: Targeted Intraoperative Radiotherapy (TARGIT)

 

Radiobiology of Targeted intraoperation radiation therapy (TARGIT): Mathematical Modelling of breast cancer growth, recurrence and intra-operative radiotherapy (IORT) 

2005    Radiation Research

2005    Cancer Research UK Award Poster

2006    Journal of Theoretical Biology

2007    Journal of Theoretical Biology

Targit boost leading to a very low recurrence rate (5-yr actuarial = 1.73%  – half the expected)

2006    International Journal or Radiation Oncology Biology Physics

2008    American Society of Clinical Oncology (ASCO)

2010     International Journal or Radiation Oncology Biology Physics

Novel effects of TARGIT on tumour micro-environment

2008    Clinical Cancer Research

2009    International Journal of Radiation Oncology Biology Physics

2016     Oncogene: Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway.

2017     Systemic Effects of local treatment : Surgery and intraoperative targeted radiotherapy

First publication of the main results of the TARGIT-A trial

2010    The Lancet.  2010 ;376(9735):91-102.

5-year results and first analysis of survival

2014    The Lancet, 11 November. doi:10.1016/s0140-6736(13)61950-9   PDF  Podcast 


Full report of TARGIT-A trial comparing Intrabeam TARGIT IORT vs traditional radiotherapy over several weeks for early breast cancer

2016  HTA Journals 

An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial). Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M. Health Technology Assessment 2016;20(73) — PDF download —

 

This contains several additional analyses including a) subgroup analysis as per tumour and patient characteristics b) formal health economic analysis c) analysis of the earliest cohort of patients with a median follow up of 5 years had the same results as the main trial, viz. – that TARGIT and EBRT had similar breast cancer control and non-breast-cancer deaths were fewer with TARGIT.

The publications from 2015-16, after the main results of the TARGIT-A trial were published as well as the initial publications (listed at the end of file) are available in the file:
TARGIT-IORT-with-Intrabeam-Further-evidence-development-2015-16-and-list-of-publications-from-1995-2014.pdf

To read, right-click this Download link to the pdf file, and save the file on your computer.
Then open using Acrobat Reader.
If you cannot see the Bookmarks pane,
click on View profile, then show/hide – navigation panes and then click on Bookmarks.
Now you should see all the 16 bookmarks and navigate through the 16 papers.

To read the list of 66 selected initial original publications please see Publications-between-1995-2014-about-the-TARGIT-IORT-Technique-and-the-TARGIT-trials.pdf The front page of this website has links to the full text PDFs of important publications http://www.targit.org.uk

Adoption and data about TARGIT-IORT from around the world and a patient's view

2014   BMC Cancer Nov 2014
French Study of 12,025 patients: Over 50% of patients having breast conservation are suitable for TARGIT IORT

2015   Breast Surg Mar-Apr 2015
Intraoperative radiotherapy of the breast for early-stage breast cancer: ready for primetime

2015   Br J Surgery May 2015
Intraoperative radiotherapy in early breast cancer

2015  Ecancermedicalscience Mar 2015
Is IORT ready for roll-out? [Yes]

2015  Breast Care 15 July 2015

Accelerated Partial Breast Irradiation in Clinical Practice

2016  Annals of Surgical Oncology 9 May 2016

TARGIT-R (Retrospective): North American Experience [of nearly 1000 patients] with Intraoperative Radiation Using Low-Kilovoltage X-Rays [Intrabeam] for Breast Cancer

2016  Oncology 15 April 2016

[Low] Frequency of Whole-Breast Radiation Therapy Following Intraoperative Radiation Therapy Due to Criteria Identified by Lumpectomy

2016  American J Surg Oct 2016

IORT with its low rate of LR and wound complications may be a reasonable alternative to whole breast irradiation for early-stage breast cancer, regardless of age.

2016   Lancet 7 May 2016:
Intraoperative radiation therapy for breast cancer: a patient’s view
2017  Ann Surg Oncol 
Keynote at American Society of Breast Surgeons

An estimated 35,000 women have had TARGIT IORT with Intrabeam for their breast cancer treatment
Worldwide Adoption of Intrabeam TARGIT IORT

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