TARGIT literature archive (1995-2018)
Clinico-Pathological and biological rationale of partial breast irradiation (PBI) and the TARGIT-A Trial
The Core trial Protocol of the Targit-A Trial
The original series of patients treated with intraoperative radiation therapy: the first full paper about Targit IORT technique
The surgical technique of targeted intraoperative radiotherapy (TARGIT) for early breast cancer treatment as used in the Targit trial
A novel one-stop out-patient treatment for small breast cancers
PhD Thesis of Jayant S Vaidya
Initial media coverage
2003 San Antonio Breast Cancer Symposium:30-minute invited presentation about the Targit trial
Acute and Late Toxicity data about the Targit approach.
Reviews, Editorials, Viewpoint and Rebuttals
2015 Red Journal Aug 2015- Editorial by the Chief Editor
“…..Many careers have been built around fractionated radiation therapy for breast cancer, and it comprises a substantial proportion of the practice of the average contemporary radiation oncologist. Depending on your perspective, intraoperative radiation therapy is thus either a very serious threat or a quantum leap forward.”
2018 The Lancet 6 Jan 2018 Targeted radiotherapy for breast cancer: Letter |
2018 BMJ Evidence Based Medicine Commentary on IMPORT-LOW trial
2019 Anticancer research
Meta-analyses confirming that targeted radiotherapy is effective in controlling breast cancer and reduces deaths heart attacks and other cancers
2016 Lancet April 2016
2016 Red Journal 13 May 2016
Mortality reduction with Partial Breast Irradiation: A meta-analysis of randomised controlled trials
2018 The Lancet 6 Jan 2018
Environmental and Social impact
2016 BMJ Open 10 May 2016
TARGIT IORT radiotherapy during lumpectomy for breast cancer could save millions of travel miles & tonnes of CO2. …plus free up thousands of hours for women with early stage breast cancer, every year.
Press release by the BMJ
Cost-effectiveness of TARGIT
Better Cosmetic outcome from TARGIT
2018 Radiation Oncology
Better Quality of Life with TARGIT
Radiobiology of Targeted intraoperation radiation therapy (TARGIT): Mathematical Modelling of breast cancer growth, recurrence and intra-operative radiotherapy (IORT)
Targit boost leading to a very low recurrence rate (5-yr actuarial = 1.73% – half the expected)
Novel effects of TARGIT on tumour micro-environment
First publication of the main results of the TARGIT-A trial
5-year results and first analysis of survival
Full report of TARGIT-A trial comparing Intrabeam TARGIT IORT vs traditional radiotherapy over several weeks for early breast cancer
An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial). Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M. Health Technology Assessment 2016;20(73) — PDF download —
This contains several additional analyses including a) subgroup analysis as per tumour and patient characteristics b) formal health economic analysis c) analysis of the earliest cohort of patients with a median follow up of 5 years had the same results as the main trial, viz. – that TARGIT and EBRT had similar breast cancer control and non-breast-cancer deaths were fewer with TARGIT.
The publications from 2015-16, after the main results of the TARGIT-A trial were published as well as the initial publications (listed at the end of file) are available in the file:
To read, right-click this Download link to the pdf file, and save the file on your computer.
Then open using Acrobat Reader.
If you cannot see the Bookmarks pane,
click on View profile, then show/hide – navigation panes and then click on Bookmarks.
Now you should see all the 16 bookmarks and navigate through the 16 papers.
To read the list of 66 selected initial original publications please see Publications-between-1995-2014-about-the-TARGIT-IORT-Technique-and-the-TARGIT-trials.pdf The front page of this website has links to the full text PDFs of important publications http://www.targit.org.uk
Adoption and data about TARGIT-IORT from around the world and a patient's view
2015 Breast Surg Mar-Apr 2015
Intraoperative radiotherapy of the breast for early-stage breast cancer: ready for primetime
2015 Br J Surgery May 2015
Intraoperative radiotherapy in early breast cancer
2015 Ecancermedicalscience Mar 2015
Is IORT ready for roll-out? [Yes]
2016 Annals of Surgical Oncology 9 May 2016
2016 Oncology 15 April 2016
2016 American J Surg Oct 2016
2016 Lancet 7 May 2016:
2017 Ann Surg Oncol
An estimated 35,000 women have had TARGIT IORT with Intrabeam for their breast cancer treatment
Worldwide Adoption of Intrabeam TARGIT IORT