National and International Guidelines include TARGIT-IORT for breast cancer
Guidelines, recommendations and consensus statements that include TARGIT-IORT for breast cancer:
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First results of TARGIT-A trial published in the Lancet on 5 July 2010
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1. St Gellen Consensus 2011.
Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, members P.
Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2011;22(8):1736-47. https://pubmed.ncbi.nlm.nih.gov/21709140
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2. Europe (EUSOMA) 2012
Biganzoli L, Wildiers H, Oakman C, Marotti L, Loibl S, Kunkler I, Reed M, Ciatto S, Voogd AC, Brain E, Cutuli B, Terret C, Gosney M, Aapro M, Audisio R.
Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). The lancet oncology 2012;13(4):e148-60. https://pubmed.ncbi.nlm.nih.gov/22469125/
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First 5-year and survival results of TARGIT-A trial published in the Lancet on Nov 2023
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3. UK 2013
Marmot M, Altman DG, Cameron DA, Dewar JA, Thompson SG, Wilcox M.
Independent UK Panel on Breast Cancer Screening replies to Michael Baum. BMJ 2013;346:f873. https://www.bmj.com/content/346/bmj.f873.full​
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4. Australia 2016
Medical Services Advisory Committee A. 1189 - Targeted intraoperative radiotherapy (IORT) for early breast cancer, 2016. http://www.msac.gov.au/internet/msac/publishing.nsf/Content/1189-public
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5. Germany 2017
German Breast G.
German S3 Guidelines: Guideline detail view: Early detection, diagnosis, therapy and follow-up of breast cancer. AWMF Online;https://register.awmf.org/de/leitlinien/detail/032-045OL.
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6. Germany 2018
Liedtke C, Jackisch C, Thill M, Thomssen C, Muller V, Janni W, Committee AGOB.
AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2018. Breast Care (Basel) 2018;13(3):196-208.
https://www.karger.com/Article/FullText/489329
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7. USA American Society of Breast Surgeons 2018
Consensus Guideline on Accelerated Partial Breast Irradiation.
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8. UK NICE 2018. https://www.nice.org.uk/guidance/ta501
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9. Europe (ESMO) 2019
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E, Committee EG. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-updagger. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2019;30(8):1194-220. https://pubmed.ncbi.nlm.nih.gov/31161190/
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10. USA American Cancer Society 2019
Radiation for breast cancer https://www.cancer.org/cancer/types/breast-cancer/treatment/radiation-for-breast-cancer.html
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11. UK British Association of Surgical Oncology 2020
Importance of discussing intraoperative radiotherapy during consultations planning breast cancer surgery https://baso.org.uk/news/baso~acs-meeting-23-november-2020-%E2%80%93-medico-legal-session.aspx
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12. Global 2020
Simcock R, Thomas TV, Estes C, Filippi AR, Katz MS, Pereira IJ, Saeed H. COVID-19:
Global radiation oncology’s targeted response for pandemic preparedness. Clinical and Translational Radiation Oncology 2020;22:55-68. https://www.sciencedirect.com/science/article/pii/S2405630820300227
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13. Global 2020
Battisti NML, Mislang AR, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Sarrio RG, Stauder R, Soto-Perez-de-Celis E, Jaklitsch M, Williams GR, O'Hanlon S, Alam M, Cairo C, Colloca G, Gil LA, Jr., Sattar S, Kantilal K, Russo C, Lichtman SM, Brain E, Kanesvaran R, Wildiers H.
Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group. J Geriatr Oncol 2020;11(8):1190-98. https://www.geriatriconcology.net/article/S1879-4068(20)30366-0/fulltext
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14. Italy 2020
Vavassori A, Tagliaferri L, Vicenzi L, D'Aviero A, Ciabattoni A, Gribaudo S, Lapadula L, Mattiucci GC, Vinante L, De Sanctis V, Vidali C, Murri R, Antonietta Gambacorta M, Mignogna M, Jereczek-Fossa BA, Donato V.
Practical indications for management of patients candidate to Interventional and Intraoperative Radiotherapy (Brachytherapy, IORT) during COVID-19 pandemic - A document endorsed by AIRO (Italian Association of Radiotherapy and Clinical Oncology) Interventional Radiotherapy Working Group. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2020;149:73-77. https://www.thegreenjournal.com/article/S0167-8140(20)30221-8/fulltext
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15. UK British Association of Surgical Oncology 2020
Pragmatic guidelines for breast cancer management during the COVID-19 pandemic (UK, Worldwide) https://baso.org.uk/media/98159/covid_19_and_breast_cancer_march_2020.pdf
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16. Europe 2020
Combs SE, Belka C, Niyazi M, Corradini S, Pigorsch S, Wilkens J, Grosu AL, Guckenberger M, Ganswindt U, Bernhardt D. First statement on preparation for the COVID-19 pandemic in large German Speaking University-based radiation oncology departments Radiation Oncology 2020;15(1). https://ro-journal.biomedcentral.com/articles/10.1186/s13014-020-01527-1
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17. Global 2020
Elghazawy H, Bakkach J, Zaghloul MS, Abusanad A, Hussein MM, Alorabi M, Eldin NB, Helal T, Zaghloul TM, Venkatesulu BP, Elghazaly H, Al-Sukhun S.
Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic. Future Oncol 2020;16(31):2551-67. https://www.futuremedicine.com/doi/10.2217/fon-2020-0574
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18. Singapore 2020
Chan JJ, Sim Y, Ow SGW, Lim JSJ, Kusumawidjaja G, Zhuang Q, Wong RX, Wong FY, Tan VKM, Tan TJY. The impact of COVID-19 on and recommendations for breast cancer care: the Singapore experience. Endocr Relat Cancer 2020;27(9):R307-R27. https://erc.bioscientifica.com/view/journals/erc/27/9/ERC-20-0157.xml
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19. France 2021
Radiotherapy of breast cancer Radiothérapie des cancers du sein
Hennequin C, Belkacémi Y, Bourgier C, Cowen D, Cutuli B, Fourquet A, Hannoun-Lévi JM, Pasquier D, Racadot S, Rivera S. Radiotherapy of breast cancer. Cancer/Radiothérapie 2022;26(1):221-30.
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20. Mexico 2021
Cárdenas-Sánchez J. Consenso mexicano sobre diagnóstico y tratamiento del cáncer mamario. Gaceta Mexicana de Oncolog�a 2022;20(92). https://www.gamo-smeo.com/files/es/gamo_21_20_supl2_001-150.pdf
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21. Spain 2023
Eraso A, Sanz J, Ibáñez R, Alonso LM, Calín A, Casamayor MC, Pla MJ, Piñero A, Ripoll F, Algara M. Primer consenso español sobre el uso de la radioterapia intraoperatoria en el cáncer de mama. Conclusiones del panel de expertos.
First Spanish consensus on the use of intraoperative radiotherapy in breast cancer. Conclusions of the expert panel Revista de Senología y Patología Mamaria - Journal of Breast Science 2023;36(3). https://www.elsevier.es/es-revista-revista-senologia-patologia-mamaria--131-articulo-primer-consenso-espanol-sobre-el-S0214158223000324
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22. Spain 2023
Eraso A. Spanish Group of Radiation Oncology of Breast Cancer (GEORM) of SEOR, Girona
A milestone in the treatment of breast cancer: the first consensus of experts in Spain on intraoperative radiotherapy
Revista de Senología y Patología Mamaria - Journal of Breast Science 2023;36:10.1016/j.senol.2023.100502 https://www.elsevier.es/es-revista-revista-senologia-patologia-mamaria--131-articulo-un-hito-el-tratamiento-del-S0214158223000567
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TARGIT-IORT is used in over 250 centres in 35 countries, and included in most national and international guidelines:
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During the COVID-19 pandemic, new guidelines for treatment of breast cancer and radiotherapy especially recommend using TARGIT-IORT because it would save patients the daily travel (and viral exposure) to radiotherapy departments:
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Global radiation oncology's targeted preparedness for COVID-19
https://www.sciencedirect.com/science/article/pii/S2405630820300227
“where the technology is available the use of IORT may obviate the need for any further outpatient treatment and should be considered an option ..”
British Association of Cancer Surgery (BASO~ACS) https://baso.org.uk/media/98159/covid_19_and_breast_cancer_march_2020.pdf
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German University Hospitals
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-020-01527-1
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Italian Association of Radiotherapy and Clinical Oncology
https://www.thegreenjournal.com/article/S0167-8140(20)30221-8/fulltext
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Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic
​https://www.futuremedicine.com/doi/10.2217/fon-2020-0574
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Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group
https://www.geriatriconcology.net/article/S1879-4068(20)30366-0/fulltext
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The impact of COVID-19 on and recommendations for breast cancer care: the Singapore experience
https://erc.bioscientifica.com/view/journals/erc/27/9/ERC-20-0157.xml
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China is increasing its use of TARGIT-IORT #breastcancer by equipping more centres with the TARGIT-IORT equipment
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TARGIT-IORT has been recommended in the following guidelines on breast cancer treatment:
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NICE, the UK National Institute for Health and Care Excellence recommended TARGIT-IORT to be used in the NHS wherever the expertise and equipment is available.
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Marmot committee on screening mammography in the UK https://www.bmj.com/content/346/bmj.f873.full
German Gynaecology Oncology group (AGO) https://www.karger.com/Article/FullText/489329
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German S3 guidelines https://www.awmf.org/leitlinien/detail/ll/032-045OL.html
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St Gallen International Breast Cancer Consensus https://pubmed.ncbi.nlm.nih.gov/21709140
European Society of Breast Cancer Specialists EUSOMA https://pubmed.ncbi.nlm.nih.gov/22469125/
European Society of Medical Oncology ESMO https://pubmed.ncbi.nlm.nih.gov/31161190/
Australian counterpart of UK NICE - the Medical Services Advisory Committee http://www.msac.gov.au/internet/msac/publishing.nsf/Content/4FB951393326D81CCA25801000123BF0/$File/1189-FinalPSD-IORTforEarlyBreastCancer-accessible.pdf
American Cancer Society https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breast-cancer.html 10/n
American Society of Breast Surgeons https://www.breastsurgeons.org/docs/statements/Consensus-Statement-for-Accelerated-Partial-Breast-Irradiation.pdf
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Mexican guidelines for breast cancer diagnosis and treatment
https://www.gamo-smeo.com/files/es/gamo_21_20_supl2_001-150.pdf
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