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National and International Guidelines include TARGIT-IORT for breast cancer

World map - TARGIT-IORT centres and countries.png
Guidelines, recommendations and consensus statements that include TARGIT-IORT for breast cancer:

 

1. St Gellen Consensus 2011. 

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, members P.

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2011;22(8):1736-47. https://pubmed.ncbi.nlm.nih.gov/21709140

2. Europe (EUSOMA) 2012

Biganzoli L, Wildiers H, Oakman C, Marotti L, Loibl S, Kunkler I, Reed M, Ciatto S, Voogd AC, Brain E, Cutuli B, Terret C, Gosney M, Aapro M, Audisio R.

Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). The lancet oncology 2012;13(4):e148-60. https://pubmed.ncbi.nlm.nih.gov/22469125/

3. UK 2013

Marmot M, Altman DG, Cameron DA, Dewar JA, Thompson SG, Wilcox M.

Independent UK Panel on Breast Cancer Screening replies to Michael Baum. BMJ 2013;346:f873. https://www.bmj.com/content/346/bmj.f873.full

4. Australia  2016

Medical Services Advisory Committee A. 1189 - Targeted intraoperative radiotherapy (IORT) for early breast cancer, 2016. http://www.msac.gov.au/internet/msac/publishing.nsf/Content/1189-public

5. Germany 2017

German Breast G.

German S3 Guidelines: Guideline detail view: Early detection, diagnosis, therapy and follow-up of breast cancer. AWMF Online;https://register.awmf.org/de/leitlinien/detail/032-045OL.

6. Germany 2018

Liedtke C, Jackisch C, Thill M, Thomssen C, Muller V, Janni W, Committee AGOB.

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2018. Breast Care (Basel) 2018;13(3):196-208. 

https://www.karger.com/Article/FullText/489329 

7. USA American Society of Breast Surgeons 2018

Consensus Guideline on Accelerated Partial Breast Irradiation.

 https://www.breastsurgeons.org/docs/statements/Consensus-Statement-for-Accelerated-Partial-Breast-Irradiation.pdf

8. UK NICE 2018. https://www.nice.org.uk/guidance/ta501

9. Europe (ESMO) 2019

Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E, Committee EG. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-updagger. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2019;30(8):1194-220. https://pubmed.ncbi.nlm.nih.gov/31161190/

10. USA American Cancer Society 2019

Radiation for breast cancer https://www.cancer.org/cancer/types/breast-cancer/treatment/radiation-for-breast-cancer.html 

11. UK British Association of Surgical Oncology 2020

Importance of discussing intraoperative radiotherapy during consultations planning  breast cancer surgery https://baso.org.uk/news/baso~acs-meeting-23-november-2020-%E2%80%93-medico-legal-session.aspx

12. Global 2020

Simcock R, Thomas TV, Estes C, Filippi AR, Katz MS, Pereira IJ, Saeed H. COVID-19:

Global radiation oncology’s targeted response for pandemic preparedness. Clinical and Translational Radiation Oncology 2020;22:55-68. https://www.sciencedirect.com/science/article/pii/S2405630820300227

13. Global 2020

Battisti NML, Mislang AR, Cooper L, O'Donovan A, Audisio RA, Cheung KL, Sarrio RG, Stauder R, Soto-Perez-de-Celis E, Jaklitsch M, Williams GR, O'Hanlon S, Alam M, Cairo C, Colloca G, Gil LA, Jr., Sattar S, Kantilal K, Russo C, Lichtman SM, Brain E, Kanesvaran R, Wildiers H.

Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group. J Geriatr Oncol 2020;11(8):1190-98. https://www.geriatriconcology.net/article/S1879-4068(20)30366-0/fulltext

14. Italy 2020

Vavassori A, Tagliaferri L, Vicenzi L, D'Aviero A, Ciabattoni A, Gribaudo S, Lapadula L, Mattiucci GC, Vinante L, De Sanctis V, Vidali C, Murri R, Antonietta Gambacorta M, Mignogna M, Jereczek-Fossa BA, Donato V.

Practical indications for management of patients candidate to Interventional and Intraoperative Radiotherapy (Brachytherapy, IORT) during COVID-19 pandemic - A document endorsed by AIRO (Italian Association of Radiotherapy and Clinical Oncology) Interventional Radiotherapy Working Group. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2020;149:73-77. https://www.thegreenjournal.com/article/S0167-8140(20)30221-8/fulltext

15. UK British Association of Surgical Oncology 2020

Pragmatic guidelines for breast cancer management during the COVID-19 pandemic (UK, Worldwide) https://baso.org.uk/media/98159/covid_19_and_breast_cancer_march_2020.pdf 

16. Europe 2020

Combs SE, Belka C, Niyazi M, Corradini S, Pigorsch S, Wilkens J, Grosu AL, Guckenberger M, Ganswindt U, Bernhardt D. First statement on preparation for the COVID-19 pandemic in large German Speaking University-based radiation oncology departments Radiation Oncology 2020;15(1). https://ro-journal.biomedcentral.com/articles/10.1186/s13014-020-01527-1

17. Global 2020

Elghazawy H, Bakkach J, Zaghloul MS, Abusanad A, Hussein MM, Alorabi M, Eldin NB, Helal T, Zaghloul TM, Venkatesulu BP, Elghazaly H, Al-Sukhun S.

Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic. Future Oncol 2020;16(31):2551-67. https://www.futuremedicine.com/doi/10.2217/fon-2020-0574

18. Singapore 2020

Chan JJ, Sim Y, Ow SGW, Lim JSJ, Kusumawidjaja G, Zhuang Q, Wong RX, Wong FY, Tan VKM, Tan TJY. The impact of COVID-19 on and recommendations for breast cancer care: the Singapore experience. Endocr Relat Cancer 2020;27(9):R307-R27. https://erc.bioscientifica.com/view/journals/erc/27/9/ERC-20-0157.xml

19. France 2021 

Radiotherapy of breast cancer Radiothérapie des cancers du sein

Hennequin C, Belkacémi Y, Bourgier C, Cowen D, Cutuli B, Fourquet A, Hannoun-Lévi JM, Pasquier D, Racadot S, Rivera S. Radiotherapy of breast cancer. Cancer/Radiothérapie 2022;26(1):221-30.

20. Mexico 2021

Cárdenas-Sánchez J. Consenso mexicano sobre diagnóstico y tratamiento del cáncer mamario. Gaceta Mexicana de Oncolog�a 2022;20(92). https://www.gamo-smeo.com/files/es/gamo_21_20_supl2_001-150.pdf

21. Spain 2023

Eraso A, Sanz J, Ibáñez R, Alonso LM, Calín A, Casamayor MC, Pla MJ, Piñero A, Ripoll F, Algara M. Primer consenso español sobre el uso de la radioterapia intraoperatoria en el cáncer de mama. Conclusiones del panel de expertos.

First Spanish consensus on the use of intraoperative radiotherapy in breast cancer. Conclusions of the expert panel    Revista de Senología y Patología Mamaria - Journal of Breast Science  2023;36(3).  https://www.elsevier.es/es-revista-revista-senologia-patologia-mamaria--131-articulo-primer-consenso-espanol-sobre-el-S0214158223000324

22. Spain 2023

Eraso A. Spanish Group of Radiation Oncology of Breast Cancer (GEORM) of SEOR, Girona 

A milestone in the treatment of breast cancer: the first consensus of experts in Spain on intraoperative radiotherapy

Revista de Senología y Patología Mamaria - Journal of Breast Science  2023;36:10.1016/j.senol.2023.100502  https://www.elsevier.es/es-revista-revista-senologia-patologia-mamaria--131-articulo-un-hito-el-tratamiento-del-S0214158223000567

TARGIT-IORT is used in over 250 centres in 35 countries, and included in most national and international guidelines: 

Click to see an interactive world map of centres where TARGIT-IORT has been offered for breast cancer 

 

During the COVID-19 pandemic, new guidelines for treatment of breast cancer and radiotherapy especially recommend using TARGIT-IORT because it would save patients the daily travel (and viral exposure) to radiotherapy departments:

Global radiation oncology's targeted preparedness for COVID-19  

https://www.sciencedirect.com/science/article/pii/S2405630820300227 

“where the technology is available the use of IORT may obviate the need for any further outpatient treatment and should be considered an option ..” 

 

British Association of Cancer Surgery (BASO~ACS) https://baso.org.uk/media/98159/covid_19_and_breast_cancer_march_2020.pdf

German University Hospitals 

https://ro-journal.biomedcentral.com/articles/10.1186/s13014-020-01527-1

Italian Association of Radiotherapy and Clinical Oncology

https://www.thegreenjournal.com/article/S0167-8140(20)30221-8/fulltext

Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic

​https://www.futuremedicine.com/doi/10.2217/fon-2020-0574

Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the International Society of Geriatric Oncology (SIOG) COVID-19 Working Group

https://www.geriatriconcology.net/article/S1879-4068(20)30366-0/fulltext

The impact of COVID-19 on and recommendations for breast cancer care: the Singapore experience

https://erc.bioscientifica.com/view/journals/erc/27/9/ERC-20-0157.xml

China is increasing its use of TARGIT-IORT #breastcancer by equipping more centres with the TARGIT-IORT equipment 

 

TARGIT-IORT has been recommended in the following guidelines on breast cancer treatment:

NICE, the UK National Institute for Health and Care Excellence recommended TARGIT-IORT to be used in the NHS wherever the expertise and equipment is available.

Marmot committee on screening mammography in the UK https://www.bmj.com/content/346/bmj.f873.full 

 

German Gynaecology Oncology group (AGO) https://www.karger.com/Article/FullText/489329 

German S3 guidelines https://www.awmf.org/leitlinien/detail/ll/032-045OL.html

St Gallen International Breast Cancer Consensus https://pubmed.ncbi.nlm.nih.gov/21709140 

 

European Society of Breast Cancer Specialists EUSOMA https://pubmed.ncbi.nlm.nih.gov/22469125/  

 

European Society of Medical Oncology ESMO https://pubmed.ncbi.nlm.nih.gov/31161190/ 

 

Australian counterpart of UK NICE - the Medical Services Advisory Committee  http://www.msac.gov.au/internet/msac/publishing.nsf/Content/4FB951393326D81CCA25801000123BF0/$File/1189-FinalPSD-IORTforEarlyBreastCancer-accessible.pdf

 

American Cancer Society  https://www.cancer.org/cancer/breast-cancer/treatment/radiation-for-breast-cancer.html 10/n

 

American Society of Breast Surgeons https://www.breastsurgeons.org/docs/statements/Consensus-Statement-for-Accelerated-Partial-Breast-Irradiation.pdf 

Mexican guidelines for breast cancer diagnosis and treatment 

https://www.gamo-smeo.com/files/es/gamo_21_20_supl2_001-150.pdf 

 

BASO guideline on medico-legal aspects of offering IORT for breast cancer.png
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