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My work on Intraoperative Radiotherapy (IORT) was inspired by original laboratory work in 1994-5, leading to the idea that breast cancer treatment with surgery and radiotherapy needs to be focussed and targeted. Working with Professor Michael Baum and Professor Jeffrey S Tobias, in UCL, London, I developed the concept, tools (Intrabeam) and the surgical operative procedure (TARGIT IORT) to give targeted intraoperative radiotherapy to the tissues immediately around a breast cancer, after it is surgically removed (lumpectomy). I named this technique TARGIT- for TARGeted Intraoperative radioTherapy and it is commonly called Intrabeam TARGIT IORT. The Intrabeam TARGIT IORT procedure has been now been used to treat in over 20,000 breast cancer patients worldwide. I would encourage the interested reader to visit the Intrabeam TARGIT IORT webpages giving the details of TARGIT-A trial. Given as a tumour bed boost, TARGIT IORT appears to achieve more than 98% durable local control in unselected cases. This has lead to the TARGIT-B trial, which will inform us whether Intrabeam TARGIT IORT given as a boost is superior to the standard radiotherapy boost.

Here are some of my talks about breast cancer research including Intrabeam TARGIT IORT.

My academic position is  Professor of Surgery and Oncology at University College London, London, UK and I am the Scientific Director of the Clinical Trials Group of the Division of Surgery, University College London and lead the Breast Cancer service at the Whittington Hospital, London.



I work as a Consultant Surgeon in London at the Whittington, Royal Free and University College London Hospitals, and see private patients at the London Breast Institute at the Princess Grace Hospital and the King Edward VII hospital where I run a One-Stop breast cancer clinic.

I have experience in all aspects of breast cancer surgery including lumpectomy, wide local excision and quadrantectomy for breast cancer including glandular reconstruction, sentinel node biopsy / axillary sampling, axillary clearance, and targeted intraoperative radiotherapy, – Intrabeam TARGIT IORT – a particular type of IORT. I work in conjunction with renowned plastic surgeons for breast reconstructive surgery. We take a multidisciplinary approach to breast cancer treatment and work very closely in a renowned team of medical oncologists, radiotherapists, radiologists and pathologists, breast care nurses, and specialists in psychosocial care.

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